Increased mitochondrial fusion via systemic OPA1 overexpression promotes dyslipidemia and atherosclerosis in LDLR deficient mice
Mitochondrial fusion mediated by OPA1 plays a key role in atherosclerosis by affecting lipoprotein metabolism and vascular smooth muscle cell biology.
Authors
- Giuseppe Danilo Norata (ORCID: https://orcid.org/0000-0002-6081-1257)
- Monika Svecla (ORCID: https://orcid.org/0000-0002-7269-7308)
- Annalisa Moregola (ORCID: https://orcid.org/0009-0001-6646-2967)
- Andreas Edsfeldt (ORCID: https://orcid.org/0000-0002-2691-9192)
- Elena Donetti (ORCID: https://orcid.org/0000-0002-5634-5863)
- Lorenzo Da Dalt (ORCID: https://orcid.org/0000-0002-6298-8689)
- Francesca Fantini (ORCID: https://orcid.org/0000-0002-1924-393X)
- Silvia Pedretti (ORCID: https://orcid.org/0000-0001-6404-6321)
- Patrizia Uboldi (ORCID: https://orcid.org/0000-0003-3036-5230)
- Jiangming Sun (ORCID: https://orcid.org/0000-0001-6814-1297)
- Luca Scorrano (ORCID: https://orcid.org/0000-0002-8515-8928)
- Isabel Gonçalves (ORCID: https://orcid.org/0000-0002-2935-0181)
- Nico Mitro (ORCID: https://orcid.org/0000-0002-5000-3619)
- Andrea Baragetti (ORCID: https://orcid.org/0000-0002-6216-1999)
- Giovanni Battista Vingiani (ORCID: https://orcid.org/0009-0004-5932-498X)
- Silvia Roda
- Giulia Giancane
Institutions
- Lund University (SE)
- University of Milan (IT)
- Veneto Institute of Molecular Medicine (IT)
- Skåne University Hospital (SE)
- European Institute of Oncology (IT)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1016/j.molmet.2025.102256
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00