Serum bilirubin concentrations and their association with clinical and radiological outcomes in multiple sclerosis: A large cohort study
MS patients have markedly lower serum bilirubin concentrations, most likely due to consumption during the increased oxidative stress since the frequencies of UGT1A1 were comparable in the MS and control populations. Higher serum bilirubin is associated with lower disability and lower brain atrophy.
Authors
- Manuela Vaněčková (ORCID: https://orcid.org/0000-0002-8784-7997)
- Tomáš Uher (ORCID: https://orcid.org/0000-0003-3160-9022)
- Jan Krásenský (ORCID: https://orcid.org/0000-0002-5605-8821)
- David Hoskovec (ORCID: https://orcid.org/0000-0003-2948-8989)
- Renata Cífková (ORCID: https://orcid.org/0000-0003-2765-3821)
- Eva Havrdová (ORCID: https://orcid.org/0000-0002-9543-4359)
- Jana Woronyczová
- Pavlína Kleinová (ORCID: https://orcid.org/0000-0002-5911-936X)
- Lubomír Štěpánek (ORCID: https://orcid.org/0000-0002-8308-4304)
- Martin Leníček (ORCID: https://orcid.org/0000-0001-6242-3488)
- Libor Vı́tek (ORCID: https://orcid.org/0000-0002-5318-0151)
- Dana Horáková
Institutions
- Charles University (CZ)
- Institute of Biophysics (HU)
- Thomayer University Hospital (CZ)
- General University Hospital in Prague (CZ)
Publication Details
- Journal
- Annals of Hepatology
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1016/j.aohep.2025.102117
- Citations
- 1
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.35