Generation of a human iPSC line (NUMNi002-A) from a patient with nephrotic syndrome harboring an INF2 gene variant
A variant of INF2 has been identified as a risk factor for nephrotic syndrome (focal segmental glomerulosclerosis; FSGS). The mechanism by which this variant contributes to FSGS onset remains unclear. Furthermore, treatment for FSGS remains to be established.We generated induced pluripotent stem cells (iPSCs) from a patient with FSGS caused by the INF2 variant. These iPSCs express stemness markers and can differentiate into the three germ layers in vitro. These iPSCs will be useful tools for understanding the pathophysiology of this type of FSGS and to screen the relevant treatment.
Authors
- Asuka Horinouchi
- Eri Ito (ORCID: https://orcid.org/0000-0003-0089-5468)
- Norio Ozaki (ORCID: https://orcid.org/0000-0002-7360-4898)
- Akiko Owaki
- Chikao Onogi (ORCID: https://orcid.org/0000-0002-7072-208X)
- Itaru Kushima
- Kumiko Fujieda (ORCID: https://orcid.org/0000-0003-2086-9507)
- Shoichi Maruyama (ORCID: https://orcid.org/0000-0002-8858-632X)
- Noritoshi Kato (ORCID: https://orcid.org/0000-0003-3924-6887)
- Kazuhiro Furuhashi (ORCID: https://orcid.org/0000-0003-2476-688X)
- Tomohiro Kawazoe
- Hangsoo Kim (ORCID: https://orcid.org/0009-0009-9248-3356)
- Akihito Tanaka (ORCID: https://orcid.org/0000-0001-8866-5901)
- Jun Matsumoto (ORCID: https://orcid.org/0000-0002-8246-8349)
- Akihisa Kato
- Yu Watanabe (ORCID: https://orcid.org/0009-0009-4297-9951)
- Kayaho Maeda
- Keita Hattori
Institutions
- Nagoya University Hospital (JP)
- Nagoya University (JP)
Publication Details
- Journal
- Stem Cell Research
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1016/j.scr.2025.103842
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 0.00