EP300/YAP1-SERPINE1 Signaling Regulates Ductular Reaction and Liver Fibrosis in Biliary Atresia
This study describes an important role of EP300/YAP1-SERPINE1 pathway in the progress of DR-associated LF. Also, our results indicate that the suppression of EP300 could be a potential approach for treating progressive LF in patients with BA.
Authors
- Wei Zhu (ORCID: https://orcid.org/0000-0003-2584-0260)
- Zequan Ding
- Yao Lü (ORCID: https://orcid.org/0000-0002-8852-4356)
- Zhongxian Zhu (ORCID: https://orcid.org/0000-0003-3379-9827)
- Changgui Lu
- Hua Xie (ORCID: https://orcid.org/0009-0007-7586-9279)
- Xiaofeng Lv
- Yufei Zhu (ORCID: https://orcid.org/0009-0001-7092-7608)
- Ruyi Zhang (ORCID: https://orcid.org/0000-0001-5596-7014)
- Jie Tang (ORCID: https://orcid.org/0000-0002-6219-8177)
Institutions
- Nanjing Children's Hospital (CN)
- Second Affiliated Hospital of Nanjing Medical University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1016/j.jcmgh.2025.101640
- Primary Topic
- Pediatric Hepatobiliary Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00