Evaluation of in vitro drug-drug interactions of ivermectin and antimalarial compounds
Several of the commonly used antimalarial drugs, are mostly or in part metabolized by CYP3A4 and showed a notable DDI effect on the in vitro metabolism of ivermectin. This could potentially lead to clinically important pharmacokinetic and pharmacodynamic DDIs if co-administered, and needs to be evaluated in prospective clinical trials.
Authors
- Phornpimon Tipthara (ORCID: https://orcid.org/0000-0002-4691-7063)
- Joel Tärning (ORCID: https://orcid.org/0000-0003-4566-4030)
- Rattawan Kullasakboonsri
- Kevin C. Kobylinski (ORCID: https://orcid.org/0000-0002-4807-9681)
Institutions
- Mahidol University (TH)
- University of Oxford (GB)
- Mahidol Oxford Tropical Medicine Research Unit (TH)
Publication Details
- Journal
- Malaria Journal
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1186/s12936-025-05516-1
- Primary Topic
- Parasitic Diseases Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wellcome Trust