Loss of Brg1 and Pten in Pancreatic Ductal Cells Forms Intraductal Tubulopapillary Neoplasm via the YAP/TAZ Pathway

Simultaneous loss of Brg1 and Pten in pancreatic ductal cells results in ITPN formation via the activation of the YAP/TAZ pathway in the mouse model. The YAP/TAZ pathway is a key driver of ITPN formation and is a potential therapeutic target for ITPN and ITPN-derived PDAC.

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Publication Details

Journal
Cellular and Molecular Gastroenterology and Hepatology
Published
2025-09-23
DOI
https://doi.org/10.1016/j.jcmgh.2025.101639
Primary Topic
Renal and related cancers
Type
article
Field-Weighted Citation Impact
0.00
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article

Loss of Brg1 and Pten in Pancreatic Ductal Cells Forms Intraductal Tubulopapillary Neoplasm via the YAP/TAZ Pathway

Shujiro Yazumi, Hiroshi Seno, Yoko Masui, Mayuki Omatsu et al.
Cellular and Molecular Gastroenterology and Hepatology
Renal and related cancers
article

Loss of Brg1 and Pten in Pancreatic Ductal Cells Forms Intraductal Tubulopapillary Neoplasm via the YAP/TAZ Pathway

Shujiro Yazumi, Hiroshi Seno, Yoko Masui, Mayuki Omatsu, Munenori Kawai, Kosuke Minaga, Kazuyuki Nagai, Takahisa Maruno, Katsutoshi Kuriyama, Takayuki Anazawa, Yuki Nakanishi, Shinnosuke Nakayama, Kenta Mizukoshi, Naoki Aoyama, Etsuro Hatano, Jorge Ferrer, Munehiro Ikeda, Akihisa Fukuda, Kei Iimori, Tatsuaki Tsuruyama, Yu Muta, Munemasa Nagao, Sho Matsuyama, Kosuke Iwane, Yuki Yamauchi, Osamu Araki, Go Yamakawa
article en

Abstract

Simultaneous loss of Brg1 and Pten in pancreatic ductal cells results in ITPN formation via the activation of the YAP/TAZ pathway in the mouse model. The YAP/TAZ pathway is a key driver of ITPN formation and is a potential therapeutic target for ITPN and ITPN-derived PDAC.

Cellular and Molecular Gastroenterology and HepatologyVol. 20(2)
Kyoto University (JP), Kyoto Medical Center (JP), Kindai University Hospital (JP), Hyogo Prefectural Amagasaki General Medical Center (JP), Centre for Genomic Regulation (ES), Kyoto Katsura Hospital (JP), Kitano Hospital (JP)
Openalex Percentile: Top 77%
Renal and related cancers
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