Loss of Brg1 and Pten in Pancreatic Ductal Cells Forms Intraductal Tubulopapillary Neoplasm via the YAP/TAZ Pathway
Simultaneous loss of Brg1 and Pten in pancreatic ductal cells results in ITPN formation via the activation of the YAP/TAZ pathway in the mouse model. The YAP/TAZ pathway is a key driver of ITPN formation and is a potential therapeutic target for ITPN and ITPN-derived PDAC.
Authors
- Shujiro Yazumi (ORCID: https://orcid.org/0000-0002-0683-0000)
- Hiroshi Seno (ORCID: https://orcid.org/0000-0002-8509-8128)
- Yoko Masui
- Mayuki Omatsu (ORCID: https://orcid.org/0000-0003-1595-7094)
- Munenori Kawai (ORCID: https://orcid.org/0000-0001-9784-1487)
- Kosuke Minaga (ORCID: https://orcid.org/0000-0001-5407-7925)
- Kazuyuki Nagai (ORCID: https://orcid.org/0000-0003-2180-2056)
- Takahisa Maruno (ORCID: https://orcid.org/0000-0002-7060-4104)
- Katsutoshi Kuriyama (ORCID: https://orcid.org/0000-0002-3985-9774)
- Takayuki Anazawa (ORCID: https://orcid.org/0000-0002-7625-5750)
- Yuki Nakanishi (ORCID: https://orcid.org/0000-0001-5493-6312)
- Shinnosuke Nakayama (ORCID: https://orcid.org/0000-0002-1048-1202)
- Kenta Mizukoshi (ORCID: https://orcid.org/0000-0002-0847-154X)
- Naoki Aoyama (ORCID: https://orcid.org/0000-0003-3978-2778)
- Etsuro Hatano (ORCID: https://orcid.org/0000-0003-3407-1918)
- Jorge Ferrer (ORCID: https://orcid.org/0000-0002-5959-5729)
- Munehiro Ikeda (ORCID: https://orcid.org/0000-0002-9117-3702)
- Akihisa Fukuda (ORCID: https://orcid.org/0000-0002-1940-596X)
- Kei Iimori (ORCID: https://orcid.org/0000-0002-9252-755X)
- Tatsuaki Tsuruyama (ORCID: https://orcid.org/0000-0002-3118-2826)
- Yu Muta (ORCID: https://orcid.org/0000-0001-5311-363X)
- Munemasa Nagao (ORCID: https://orcid.org/0000-0003-0789-6623)
- Sho Matsuyama (ORCID: https://orcid.org/0009-0000-2248-5692)
- Kosuke Iwane
- Yuki Yamauchi
- Osamu Araki (ORCID: https://orcid.org/0000-0002-5205-556X)
- Go Yamakawa
Institutions
- Kyoto University (JP)
- Kyoto Medical Center (JP)
- Kindai University Hospital (JP)
- Hyogo Prefectural Amagasaki General Medical Center (JP)
- Centre for Genomic Regulation (ES)
- Kyoto Katsura Hospital (JP)
- Kitano Hospital (JP)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1016/j.jcmgh.2025.101639
- Primary Topic
- Renal and related cancers
- Type
- article
- Field-Weighted Citation Impact
- 0.00