The Glycolysis-HIF-1α axis induces IL-1β of macrophages in rheumatoid arthritis
Our findings demonstrate that RA serum triggers aerobic glycolysis in macrophages, which promotes HIF-1α to drive IL-1β production. Notably, IL-1β within RA serum amplifies its own expression via this glycolysis-HIF-1α axis, establishing a pathogenic positive feedback loop in RA.
Authors
- Yunyun Fei (ORCID: https://orcid.org/0000-0001-8743-7376)
- Xunyao Wu (ORCID: https://orcid.org/0000-0003-4852-0606)
- Huaxia Yang (ORCID: https://orcid.org/0000-0001-6811-0255)
- Lidan Zhao
- Yimeng Jia (ORCID: https://orcid.org/0009-0005-7111-3437)
- Xin You (ORCID: https://orcid.org/0000-0002-3546-1291)
- Rongli Li (ORCID: https://orcid.org/0000-0003-4048-5703)
- Linfang Huang
Institutions
- Hunan Institute of Science and Technology (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- First People's Hospital of Yunnan Province (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Yueyang Second People's Hospital (CN)
- Yueyang Hospital (CN)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2025-09-26
- DOI
- https://doi.org/10.1186/s13075-025-03647-z
- Citations
- 4
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 3.19
Funders
- National Children's Research Centre
- National Natural Science Foundation of China
- Peking Union Medical College Hospital