Click Synthesis and Spectral Characterization of a 1,2,3-Triazole Conjugated Pyrrole-2,5-dione Scaffold

This study presents the synthesis and characterization of a novel 1,2,3-triazole conjugated pyrrole-2,5-dione compound via copper-catalyzed azide-alkyne cycloaddition (click chemistry). The synthetic route involves the reaction of benzyl azide with a pyrrole-2,5-dione-derived alkyne under mild conditions, yielding the target compound in excellent purity and yield (92 percent). The final product was comprehensively characterized using FT-IR, <sup>1</sup>H-NMR, <sup>13</sup>C-NMR, and high-resolution mass spectrometry, confirming its structural integrity. The reported methodology contributes to the development of bioactive heterocyclic scaffolds with potential pharmaceutical relevance.

Authors

Publication Details

Journal
International Journal of Science and Research (IJSR)
Published
2025-09-26
DOI
https://doi.org/10.21275/sr25923100202
Primary Topic
Synthesis and Characterization of Pyrroles
Type
article
Field-Weighted Citation Impact
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article

Click Synthesis and Spectral Characterization of a 1,2,3-Triazole Conjugated Pyrrole-2,5-dione Scaffold

Ram Kumar, V. Anil Kumar, Nitesh Kumar, Saba Khan et al.
International Journal of Science and Research (IJSR)
Synthesis and Characterization of Pyrroles
article

Click Synthesis and Spectral Characterization of a 1,2,3-Triazole Conjugated Pyrrole-2,5-dione Scaffold

Ram Kumar, V. Anil Kumar, Nitesh Kumar, Saba Khan, Urvashi Mishra
article en

Abstract

This study presents the synthesis and characterization of a novel 1,2,3-triazole conjugated pyrrole-2,5-dione compound via copper-catalyzed azide-alkyne cycloaddition (click chemistry). The synthetic route involves the reaction of benzyl azide with a pyrrole-2,5-dione-derived alkyne under mild conditions, yielding the target compound in excellent purity and yield (92 percent). The final product was comprehensively characterized using FT-IR, <sup>1</sup>H-NMR, <sup>13</sup>C-NMR, and high-resolution mass spectrometry, confirming its structural integrity. The reported methodology contributes to the development of bioactive heterocyclic scaffolds with potential pharmaceutical relevance.

International Journal of Science and Research (IJSR)
Openalex Percentile: Top 80%
Synthesis and Characterization of Pyrroles
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