POU4F1 Drives Colorectal Cancer Progression by Promoting Cell Proliferation, Metastasis, and Chemoresistance

This study successfully identified crucial genes associated with colorectal cancer recurrence and developed a robust RAGS prognostic model. The XGBoost algorithm underscored the importance of POU4F1 in predicting colorectal cancer recurrence. Our functional analysis of POU4F1 provides fresh insights into colorectal cancer progression mechanisms and informs the development of targeted therapeutic approaches. These findings not only enhance our understanding of colorectal cancer's molecular underpinnings but also establish a solid foundation for advancing precision diagnosis and treatment in clinical practice.

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Publication Details

Journal
Digestion
Published
2025-09-25
DOI
https://doi.org/10.1159/000548266
Primary Topic
Colorectal Cancer Treatments and Studies
Type
article
Field-Weighted Citation Impact
0.00
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article

POU4F1 Drives Colorectal Cancer Progression by Promoting Cell Proliferation, Metastasis, and Chemoresistance

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Digestion
Colorectal Cancer Treatments and Studies
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POU4F1 Drives Colorectal Cancer Progression by Promoting Cell Proliferation, Metastasis, and Chemoresistance

Hui-Guang Li, Fangqin Xue, Ping Gao, Qingshui Wang, Chao Xu
article en

Abstract

This study successfully identified crucial genes associated with colorectal cancer recurrence and developed a robust RAGS prognostic model. The XGBoost algorithm underscored the importance of POU4F1 in predicting colorectal cancer recurrence. Our functional analysis of POU4F1 provides fresh insights into colorectal cancer progression mechanisms and informs the development of targeted therapeutic approaches. These findings not only enhance our understanding of colorectal cancer's molecular underpinnings but also establish a solid foundation for advancing precision diagnosis and treatment in clinical practice.

DigestionVol. 107(2)
Fujian University of Traditional Chinese Medicine (CN), Fujian Medical University (CN), China National Pharmaceutical Group Corporation (China) (CN), Fujian Provincial Hospital (CN)
Openalex Percentile: Top 64%
Colorectal Cancer Treatments and Studies
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