Functional Mapping of Epigenomic Regulators Uncovers Coordinated Tumor Suppression by the HBO1 and MLL1 Complexes
Using a novel functional genomics method in vivo, we investigated epigenomic regulators in lung tumorigenesis. We discovered multiple novel genes that affect tumor growth. We show that the HBO1 and MLL1 complexes interact to suppress lung adenocarcinoma. Our findings provide broad insights into the epigenomic regulatory landscape of lung cancer.
Authors
- Laura Andrejka (ORCID: https://orcid.org/0000-0002-2202-5626)
- Paloma Ruiz (ORCID: https://orcid.org/0000-0001-6208-5087)
- Yuning J. Tang (ORCID: https://orcid.org/0009-0006-7037-2901)
- Sarah E. Pierce (ORCID: https://orcid.org/0000-0002-9145-9559)
- Jess D. Hebert (ORCID: https://orcid.org/0000-0002-8778-5941)
- Deniz Nesli Dolcen (ORCID: https://orcid.org/0000-0003-2441-7313)
- Matt van de Rijn (ORCID: https://orcid.org/0000-0002-1909-9739)
- Emily G. Shuldiner (ORCID: https://orcid.org/0000-0002-5018-0500)
- Emily L. Ashkin (ORCID: https://orcid.org/0000-0001-7363-7860)
- Anne K. Voss (ORCID: https://orcid.org/0000-0002-3853-9381)
- Haiqing Xu (ORCID: https://orcid.org/0000-0002-9124-3192)
- Monte M. Winslow (ORCID: https://orcid.org/0000-0002-5730-9573)
- William J. Greenleaf (ORCID: https://orcid.org/0000-0003-1409-3095)
- Saswati Karmakar (ORCID: https://orcid.org/0000-0003-0315-5924)
- Christian A. Kunder (ORCID: https://orcid.org/0000-0003-1514-7550)
- Tim Thomas (ORCID: https://orcid.org/0000-0002-7623-8344)
- Dmitri A. Petrov (ORCID: https://orcid.org/0000-0002-3664-9130)
- Gábor Boross (ORCID: https://orcid.org/0000-0002-7208-5678)
- Samuel H. Kim (ORCID: https://orcid.org/0000-0001-8353-6190)
- Colin Detrick (ORCID: https://orcid.org/0009-0002-4115-1668)
- Steven S. Lopez (ORCID: https://orcid.org/0009-0008-0926-0016)
- Nicholas W. Hughes (ORCID: https://orcid.org/0000-0001-9004-6288)
- Pauline Chu (ORCID: https://orcid.org/0000-0001-6561-6453)
Institutions
- The University of Melbourne (AU)
- Walter and Eliza Hall Institute of Medical Research (AU)
- Guardant (United States) (US)
- HUN-REN Centre for Ecological Research (HU)
- Stanford Medicine (US)
- National Center for Epidemiology (HU)
- Stanford University (US)
Publication Details
- Journal
- Cancer Discovery
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1158/2159-8290.cd-24-1565
- Citations
- 1
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.94