Multi-omics mediation pipeline reveals differential pathways of maternal SNPs affecting newborn adiposity outcomes

Our results reveal broad patterns in the effects of maternal genetic variants on newborn adiposity, and identify both new genetic loci and loci known from previous literature to influence newborn adiposity. These results demonstrate the potential for scientific discovery enabled by our multi-omics mediation pipeline, and the approach is broadly applicable for untangling path-specific contributions in the modern integrated multi-omics landscape.