Статистическая оценка состояния некоторых показателей крови и цитогенетических показателей при экспериментальном ожоге и облучении с применением соединений TVA, TVS и TVV

In the study, a cytogenetic and hematological screening of new synthesized chemical complexes was carried out: TVA, TVS and TVV. When comparing the hematological indices of experimental rats with “clean burns” at different periods of the study (3, 7, 14, 21 and 30 days), starting from the 3rd day, the blood clotting time in all 3 groups was significantly prolonged. In the TVS group, this index retained a reliable value until the end of the observation. The number of leukocytes in 3 groups increases with the introduction of the compounds in all periods of the study. The studied compounds contribute to the elongation of the blood clot, to the decrease in the number of platelets and the percentage of hematocrit, which indicates correlation of these indicators in regulating blood clotting in burns that occur due to plasma loss through the wound surface. Having analyzed survival (irradiation), the best result was recorded with irradiation + TVA (90%), in the case of TVS and TVV, the survival rate was 80% (control group – pure irradiation – 40%). Hemodynamic changes in burns are manifested by non-specific reactions: a drop in SCC (compared to intact), a sharp increase in blood viscosity, apparently indicating increased aggregation of erythrocytes, an increase in the level of Hb and Ht, indicating hemoconcentration. Summarizing the karyotyping indices for thermal burns and irradiation, it can be said that the TVA compound has the most positive results, while the TVV compound has shown little effect.