Insulin-like growth factor-I and symptoms of acromegaly according to time since somatostatin receptor ligand injection
IGF-I concentrations increased according to time since SRL injection. Patient-reported outcomes fluctuated, correlating with IGF-I and sαKL changes. Measuring IGF-I at the end of the injection cycle is advisable. Decreases in SRL concentration suggest phase-based differences in IGF-I concentrations. These findings inform personalized approaches to acromegaly, with titration of therapy based on individual IGF-I and/or PROMs fluctuation.
Authors
- Lisa B. Nachtigall (ORCID: https://orcid.org/0000-0002-5708-5231)
- Júnia Ribeiro de Oliveira Longo Schweizer (ORCID: https://orcid.org/0000-0002-8050-9127)
- Vincent Chi‐Chung Cheng (ORCID: https://orcid.org/0000-0003-1765-7706)
- Pamela S. Jones (ORCID: https://orcid.org/0000-0002-4573-3641)
- Michelle M. Adams (ORCID: https://orcid.org/0000-0002-5249-6461)
- Nicholas A. Tritos (ORCID: https://orcid.org/0000-0001-8867-607X)
- Martin Bidlingmaier (ORCID: https://orcid.org/0000-0002-4681-6668)
- Alberto Moscona-Nissan (ORCID: https://orcid.org/0000-0002-0141-7591)
- Karen J. P. Liebert
- Katharina Schilbach (ORCID: https://orcid.org/0000-0002-8667-0296)
- Ilan Remba-Shapiro (ORCID: https://orcid.org/0000-0002-5149-3680)
- Jessica Naredo Rojas
Institutions
- Harvard University (US)
- Brown University (US)
- LMU Klinikum (DE)
- Massachusetts General Hospital (US)
- Ludwig-Maximilians-Universität München (DE)
- Deggendorf Institute of Technology (DE)
Publication Details
- Journal
- European Journal of Endocrinology
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1093/ejendo/lvaf200
- Citations
- 3
- Primary Topic
- Pituitary Gland Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.88