Causal analysis of uterine artery pulsatility index-related proteins and the risk of precocious puberty in girls: a Mendelian randomization study

Our findings suggest that while arterial stiffness and other MMPs do not have a significant causal role, MMP9 may significantly increase the risk of precocious puberty in girls.

Authors

Yi Gao (ORCID: https://orcid.org/0000-0002-6080-7557)
Fengfeng Qi

Institutions

Huzhou Women and Children's Hospital (CN)

Publication Details

Journal: Journal of Pediatric Endocrinology and Metabolism
Published: 2025-09-25
DOI: https://doi.org/10.1515/jpem-2025-0073
Primary Topic: Genetic Associations and Epidemiology
Type: article
Field-Weighted Citation Impact: 0.00

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article

Causal analysis of uterine artery pulsatility index-related proteins and the risk of precocious puberty in girls: a Mendelian randomization study

Yi Gao, Fengfeng Qi

Sep 25, 2025

Journal of Pediatric Endocrinology and Metabolism

Genetic Associations and Epidemiology

article

Causal analysis of uterine artery pulsatility index-related proteins and the risk of precocious puberty in girls: a Mendelian randomization study

Yi Gao, Fengfeng Qi

September 25, 2025article en

Abstract

Our findings suggest that while arterial stiffness and other MMPs do not have a significant causal role, MMP9 may significantly increase the risk of precocious puberty in girls.

Journal of Pediatric Endocrinology and MetabolismVol. 38(11)

Huzhou Women and Children's Hospital (CN)

Openalex Percentile: Top 72%

Genetic Associations and Epidemiology

DOI Source OpenAlex

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Causal analysis of uterine artery pulsatility index-related proteins and the risk of precocious puberty in girls: a Mendelian randomization study — Yi Gao, Fengfeng Qi · Journal of Pediatric Endocrinology and Metabolism (2025) | TGRS Research Map | TGRS