High-throughput behavioural phenotyping of 25 C. elegans disease models including patient-specific mutations
Our findings show that scalable behavioural phenotyping can capture a wide range of mutant effects-from strong to subtle-in patient-avatar worm lines. We anticipate that this standardized approach will enable systematic drug repurposing for rare genetic disorders as new disease variants are discovered.
Authors
- Consuelo Barroso (ORCID: https://orcid.org/0000-0002-0661-3460)
- Lara Menzies (ORCID: https://orcid.org/0000-0003-3710-501X)
- Emma Lara Navarro (ORCID: https://orcid.org/0000-0003-1468-3693)
- André EX Brown (ORCID: https://orcid.org/0000-0002-1324-8764)
- Enrique Martínez-Pérez (ORCID: https://orcid.org/0000-0001-5813-0383)
- Thomas O’Brien (ORCID: https://orcid.org/0000-0002-5529-331X)
- David Carling
Institutions
- University of Leeds (GB)
- Great Ormond Street Hospital for Children NHS Foundation Trust (GB)
- MRC London Institute of Medical Sciences (GB)
- Imperial College London (GB)
Publication Details
- Journal
- BMC Biology
- Published
- 2025-09-26
- DOI
- https://doi.org/10.1186/s12915-025-02368-8
- Citations
- 1
- Primary Topic
- Genetics, Aging, and Longevity in Model Organisms
- Type
- article
- Field-Weighted Citation Impact
- 0.95
Funders
- Wellcome Trust
- European Commission
- Medical Research Council