Construction of the Tetracyclic Core of Isoabietenin A
Isoabietenin A is a newly isolated aromatic abietane with a complex tetracyclic framework. Herein, we report a concise construction of its characteristic 6/6/6/5 tetracyclic core enabled by an intramolecular aryne Diels-Alder cycloaddition reaction. The required <i>trans</i>-fused pattern between rings A and B was assembled by an allylic diazene rearrangement reaction.
Authors
- Xingang Xie (ORCID: https://orcid.org/0000-0002-0707-1229)
- Huaxuan Zhang (ORCID: https://orcid.org/0000-0003-1675-3480)
- Xujuan Su
- Xuegong She (ORCID: https://orcid.org/0000-0002-3002-2433)
- Ning Liang
- Yue Liu (ORCID: https://orcid.org/0009-0001-6279-7815)
Institutions
- State Key Laboratory of Chemical Engineering (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1021/acs.orglett.5c03589
- Primary Topic
- Biological Activity of Diterpenoids and Biflavonoids
- Type
- article
- Field-Weighted Citation Impact
- 0.00