Integrating genetic and transcriptomic data to identify genes underlying obesity risk loci
The identified genes help link the genetic variation at obesity-risk loci to biological mechanisms and health outcomes, thus translating GWAS findings to function.
Authors
- Anita L. DeStefano (ORCID: https://orcid.org/0000-0002-9335-2819)
- Daniel L. Levy (ORCID: https://orcid.org/0000-0002-7853-3275)
- Sudha S. Seshadri (ORCID: https://orcid.org/0000-0001-6135-2622)
- Ruth J. F. Loos (ORCID: https://orcid.org/0000-0002-8532-5087)
- Honghuang Lin (ORCID: https://orcid.org/0000-0003-3043-3942)
- Lauren E. Petty (ORCID: https://orcid.org/0000-0003-1619-6303)
- Geetha Chittoor (ORCID: https://orcid.org/0000-0001-6443-6012)
- Christopher D. Still (ORCID: https://orcid.org/0000-0001-8006-8483)
- Jennifer E Below (ORCID: https://orcid.org/0000-0002-1346-1872)
- Jerome I. Rotter (ORCID: https://orcid.org/0000-0001-7191-1723)
- Tooraj Mirshahi (ORCID: https://orcid.org/0000-0002-0754-3820)
- Mariaelisa Graff (ORCID: https://orcid.org/0000-0001-6380-1735)
- Karen L. Mohlke (ORCID: https://orcid.org/0000-0001-6721-153X)
- Joseph B. McCormick (ORCID: https://orcid.org/0000-0002-5844-8102)
- Nancy L. Heard‐Costa (ORCID: https://orcid.org/0000-0001-9730-0306)
- Anne E. Justice (ORCID: https://orcid.org/0000-0002-8903-8712)
- Kari E. North (ORCID: https://orcid.org/0000-0002-8903-0366)
- Mohammad Yaser Anwar (ORCID: https://orcid.org/0000-0002-2349-8214)
- Jennifer A. Brody (ORCID: https://orcid.org/0000-0001-8509-148X)
- Ian Dinsmore (ORCID: https://orcid.org/0000-0002-6134-8997)
- Ching‐Ti Liu (ORCID: https://orcid.org/0000-0002-0703-0742)
- Hung‐Hsin Chen (ORCID: https://orcid.org/0000-0002-1921-2797)
- Abbey Kollu
- Shreyash Gupta
- Hanfei Xu (ORCID: https://orcid.org/0000-0003-1318-0816)
- Anne Marie Cawley
- Susan P. Fisher-Hoch
- L. Adrienne Cupples
Institutions
- Boston University (US)
- University of North Carolina at Chapel Hill (US)
- University of Copenhagen (DK)
- National Institutes of Health (US)
- University of Massachusetts Chan Medical School (US)
- University of Washington (US)
- Novo Nordisk Foundation (DK)
- UCLA Medical Center (US)
- Institute of Biomedical Sciences, Academia Sinica (TW)
- Lung Institute (US)
- Institute of Sociology, Academia Sinica (TW)
- National Heart, Lung, and Blood Institute (US)
- Institute of Physics, Academia Sinica (TW)
- Institute for Neurodegenerative Disorders (US)
- Brownsville Public Library (US)
- The University of Texas Health Science Center (US)
- Genomic Health (United States) (US)
- Harbor–UCLA Medical Center (US)
- Geisinger Health System (US)
- Vanderbilt University Medical Center (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- International Journal of Obesity
- Published
- 2025-09-26
- DOI
- https://doi.org/10.1038/s41366-025-01898-z
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Health and Human Services
- Regeneron Pharmaceuticals
- Georgia Clinical and Translational Science Alliance
- National Institutes of Health
- National Institute on Aging
- National Heart, Lung, and Blood Institute
- National Institute of Diabetes and Digestive and Kidney Diseases
- Center for Information Technology
- National Center on Minority Health and Health Disparities
- National Center for Advancing Translational Sciences
- NHLBI Division of Intramural Research