Malignant Mucosal Melanoma of the Paranasal Sinuses

Sinonasal melanoma is a rare malignant tumor arising from the melanocytes of the paranasal sinuses. It has local and distant metastasis. This study reports a case of sinonasal melanoma at King Abdullah Medical Center. A 74-year-old male patient presented with unilateral nasal obstruction and epistaxis. A contrast-enhanced CT scan of the brain and paranasal sinuses showed findings suggestive of invasive fungal sinusitis. Following this finding, the patient was referred for an MRI scan, which confirmed the aggressive nature of the mass. Subsequently, a biopsy was taken from the mass, which proved sinonasal melanoma. The patient underwent surgical resection of the lesion. Histopathology confirmed the diagnosis of sinonasal melanoma. Unfortunately, the patient passed away one week after the operation.

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Publication Details

Journal
Cureus
Published
2025-09-26
DOI
https://doi.org/10.7759/cureus.93257
Primary Topic
Cutaneous Melanoma Detection and Management
Type
article
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0.00
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article

Malignant Mucosal Melanoma of the Paranasal Sinuses

Afsheen Mahboob, Naglaa Mostafa Elsayed, Aisha Almassawi
Cureus
Cutaneous Melanoma Detection and Management
article

Malignant Mucosal Melanoma of the Paranasal Sinuses

Afsheen Mahboob, Naglaa Mostafa Elsayed, Aisha Almassawi
article en

Abstract

Sinonasal melanoma is a rare malignant tumor arising from the melanocytes of the paranasal sinuses. It has local and distant metastasis. This study reports a case of sinonasal melanoma at King Abdullah Medical Center. A 74-year-old male patient presented with unilateral nasal obstruction and epistaxis. A contrast-enhanced CT scan of the brain and paranasal sinuses showed findings suggestive of invasive fungal sinusitis. Following this finding, the patient was referred for an MRI scan, which confirmed the aggressive nature of the mass. Subsequently, a biopsy was taken from the mass, which proved sinonasal melanoma. The patient underwent surgical resection of the lesion. Histopathology confirmed the diagnosis of sinonasal melanoma. Unfortunately, the patient passed away one week after the operation.

CureusVol. 17(9)
Cairo University (EG), King Abdulaziz University (SA), King Abdullah International Medical Research Center (SA), King Abdullah Medical City (SA)
Openalex Percentile: Top 64%
Cutaneous Melanoma Detection and Management
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