A novel single-vector featuring bidirectional promoters for production of bispecific antibody against rabies virus
We developed peaSKYA single-vector expression system for robust production of bispecific antibodies, with candidate HHDVD exhibiting potential in Rabies PEP. This streamlined vector design approach exhibited remarkable potential in bispecific neutralizing antibody development, offering a transferable platform for other engineered bispecific antibodies.
Authors
- Guanfeng Lin (ORCID: https://orcid.org/0000-0002-1150-9625)
- Jia Li (ORCID: https://orcid.org/0000-0002-2270-9876)
- Shouchun Cao (ORCID: https://orcid.org/0000-0001-6212-260X)
- Yingsong Wu
- Zhigao Zhang (ORCID: https://orcid.org/0000-0002-4601-5414)
Institutions
- China Banking Regulatory Commission (CN)
- National Institutes for Food and Drug Control (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- BMC Biotechnology
- Published
- 2025-09-26
- DOI
- https://doi.org/10.1186/s12896-025-01036-7
- Primary Topic
- Rabies epidemiology and control
- Type
- article
- Field-Weighted Citation Impact
- 0.00