Cryptococcus neoformans tibial osteomyelitis in an immunocompetent host: a case diagnosed by tNGS
we report a case of tibial osteomyelitis caused by Cryptococcus neoformans in an immunocompetent patient, with diagnosis confirmed through targeted next-generation sequencing (tNGS) and serum Cryptococcal capsular antigen testingOur results demonstrate the great potential of tNGS in the detection of infectious pathogens. In patients with negative culture results, tNGS can quickly detect various pathogens, providing accurate diagnosis and facilitating appropriate treatment for patients.
Authors
- Huanhuan Wei (ORCID: https://orcid.org/0000-0002-3692-4710)
- Liyan Zhou (ORCID: https://orcid.org/0000-0002-4693-8171)
- Weijuan Qin (ORCID: https://orcid.org/0000-0001-9592-2056)
- Yuni Guo
- Shao‐Lin Tan (ORCID: https://orcid.org/0000-0001-9977-7773)
- Lixin Xie (ORCID: https://orcid.org/0009-0006-8117-2067)
- Xiaoning Wu (ORCID: https://orcid.org/0000-0003-2213-7836)
- Hongbo Huang
- Zhengyi Liang (ORCID: https://orcid.org/0000-0002-4588-8600)
Institutions
- Guangxi Medical University (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
Publication Details
- Journal
- BMC Infectious Diseases
- Published
- 2025-09-26
- DOI
- https://doi.org/10.1186/s12879-025-11451-y
- Citations
- 3
- Primary Topic
- Fungal Infections and Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.06
Funders
- National Natural Science Foundation of China