Treg cell-derived exosomal miR-21 promotes osteogenic differentiation of periodontal ligament stem cells
Treg cell-derived exosomal miR-21 promotes the osteogenic differentiation of PDLSCs, enhancing periodontal tissue regeneration in vivo, suggesting that Treg cells and their exosomal miR-21 may serve as promising therapeutic targets for periodontitis.
Authors
- Yu Xia (ORCID: https://orcid.org/0000-0002-5596-5518)
- Zhen Liu (ORCID: https://orcid.org/0000-0002-1500-1757)
- Jifeng Yu (ORCID: https://orcid.org/0000-0003-2365-4560)
- Chen Wang (ORCID: https://orcid.org/0000-0002-2725-601X)
- Li Liang (ORCID: https://orcid.org/0009-0002-1362-4309)
- Hui Gao
- Nan Yang
- Hao Jiang (ORCID: https://orcid.org/0009-0008-2384-451X)
Institutions
- Chinese PLA General Hospital (CN)
- Beijing Children’s Hospital (CN)
Publication Details
- Journal
- BMC Oral Health
- Published
- 2025-09-26
- DOI
- https://doi.org/10.1186/s12903-025-06770-0
- Citations
- 3
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- National Natural Science Foundation of China