GLP1R and OCT1 variants modulate semaglutide and metformin response in type 2 diabetes
Semaglutide outperformed metformin for short-term weight loss. An HDL signal for OCT1 rs34130495 at an exploratory 10% FDR warrants replication. These hypothesis-generating data support the feasibility of genotype-guided studies in local clinical settings.
Authors
- Ivan Tourtourikov (ORCID: https://orcid.org/0000-0003-3094-8030)
- Tanya Kadiyska (ORCID: https://orcid.org/0000-0002-7030-4216)
- Rene Mileva-Popova (ORCID: https://orcid.org/0009-0005-6992-1259)
- Radka Tafradjiiska-Hadjiolova (ORCID: https://orcid.org/0000-0003-1693-2673)
- Ivanov Pa (ORCID: https://orcid.org/0000-0003-0350-8021)
- Teodora Handjieva‐Darlenska (ORCID: https://orcid.org/0000-0001-8307-343X)
- Mariya Kalinkova (ORCID: https://orcid.org/0009-0009-9338-4181)
Institutions
- University Medical Center (US)
- Medical University of Sofia (BG)
- DNA Diagnostic (Denmark) (DK)
Publication Details
- Journal
- Pharmacogenetics and Genomics
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1097/fpc.0000000000000577
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00