Wound healing effects of exosomes from hypoxia- and normoxia-expanded adipose-derived stem cells of infant and adult origin
Infant ADSC-Exos demonstrated inherent advantages under normoxic conditions, including enhanced effects on cell proliferation, migration and wound regeneration. While hypoxic preconditioning enhanced the efficacy of adult ADSC-Exos, it provided limited additional benefit to infant-derived exosomes, highlighting their intrinsic suitability for regenerative therapies.
Authors
- Jung‐Pan Wang (ORCID: https://orcid.org/0000-0002-8427-9963)
- Kuang‐Kai Hsueh (ORCID: https://orcid.org/0000-0003-2494-4666)
- Yu‐Ting Liao (ORCID: https://orcid.org/0000-0002-4491-7182)
- Ming-Te Cheng
- Ze‐Wei Tao (ORCID: https://orcid.org/0000-0003-0820-3964)
- Szu-Hsien Wu
Institutions
- National Yang Ming Chiao Tung University (TW)
- Chung Yuan Christian University (TW)
- National Tsing Hua University (TW)
- Taipei Veterans General Hospital (TW)
- Ministry of Health and Welfare (TW)
- National Defense Medical Center (TW)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-09-26
- DOI
- https://doi.org/10.1186/s13287-025-04636-4
- Citations
- 1
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Taipei Veterans General Hospital
- Tao Yuan General Hospital, Ministry of Health and Welfare