The association between dietary total antioxidant capacity and gene expression of Klotho in Iranians
These findings demonstrate that higher dietary antioxidant intake, particularly zinc, is significantly associated with increased Klotho gene expression, suggesting a potential mechanism by which antioxidant-rich diets may influence aging processes. This study provides novel evidence linking DTAC to Klotho expression in humans, supporting further investigation into dietary strategies for modulating aging-related pathways.
Authors
- Hamid Zand (ORCID: https://orcid.org/0000-0001-7278-9125)
- Zahra Rahimi Khalifeh Kandi (ORCID: https://orcid.org/0000-0001-5914-404X)
- Mahmoud Mirhoseini (ORCID: https://orcid.org/0000-0002-3721-7145)
- Arman Ghorbani (ORCID: https://orcid.org/0000-0002-1591-7319)
- Ghazaleh Eslamian (ORCID: https://orcid.org/0000-0002-8960-5123)
- Safoura Vasheghani Farahani
Institutions
- Iran University of Medical Sciences (IR)
- National Nutrition and Food Technology Research Institute (IR)
- Shahid Beheshti University of Medical Sciences (IR)
Publication Details
- Journal
- Genes & Nutrition
- Published
- 2025-09-26
- DOI
- https://doi.org/10.1186/s12263-025-00776-7
- Primary Topic
- Parathyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shahid Beheshti University of Medical Sciences
- National Nutrition and Food Technology Research Institute