The concurrent silencing of Tim-3 and STAT-3 promotes tumor regression both in vitro and in ovo
These results revealed that the concurrent silencing of Tim-3 and STAT-3 can significantly suppresses the tumor growth by reducing cell proliferation, angiogenesis and metastasis in vitro and in ovo. However, future investigations-particularly in vivo models-are necessary to validate the current strategy as a potential anti-tumor therapeutic approach.
Authors
- Farzaneh Sadat Eshaghi (ORCID: https://orcid.org/0000-0002-5600-5498)
- Atefeh Khodakarami (ORCID: https://orcid.org/0000-0001-6507-5482)
- Farbod Ebrahimi (ORCID: https://orcid.org/0000-0003-1461-6546)
- Mahsa Nikdel
- Farhad Jadidi‐Niaragh (ORCID: https://orcid.org/0000-0002-4641-882X)
- Tohid Kazemi
- Bentolhoda Rashidi
- Hasti Moshtagh Mehr
- Reza Karami
- Shahla Khodayari
Institutions
- Tabriz University of Medical Sciences (IR)
- University of Tabriz (IR)
- Azarbaijan Shahid Madani University (IR)
- University of Duisburg-Essen (DE)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1186/s12885-025-14830-5
- Primary Topic
- Galectins and Cancer Biology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Tabriz University of Medical Sciences
- University of Tabriz