Sex differences in chemotherapy completion, toxicities, and survival in colon cancer: an analysis of 2201 patients from CALGB/SWOG 80702 (Alliance)
Our findings suggested that women with colon cancer are more likely to have worse chemotherapy completion rates and more severe adverse events, but they have better survival. Sex as a biological variable warrants further consideration in chemotherapy administration and survivorship management after colon cancer diagnosis.
Authors
- Chaoyuan Kuang (ORCID: https://orcid.org/0000-0002-8984-3906)
- Smitha Krishnamurthi (ORCID: https://orcid.org/0000-0003-2411-3504)
- Jeffrey A. Meyerhardt (ORCID: https://orcid.org/0000-0002-1120-0898)
- Chao Ma (ORCID: https://orcid.org/0000-0001-7741-818X)
- Ardaman Shergill (ORCID: https://orcid.org/0000-0002-8244-2704)
- En Cheng (ORCID: https://orcid.org/0000-0001-9523-9310)
- Qian Shi (ORCID: https://orcid.org/0000-0002-4640-8832)
- Benjamin Kye Jyn Tan (ORCID: https://orcid.org/0000-0002-9411-6164)
- Justin C. Brown (ORCID: https://orcid.org/0000-0001-7540-4913)
- Thomas E. Rohan (ORCID: https://orcid.org/0000-0001-6897-4045)
- Anthony F. Shields (ORCID: https://orcid.org/0000-0002-9122-1014)
- Eileen Mary O'Reilly (ORCID: https://orcid.org/0000-0002-8076-9199)
- Kimmie Ng (ORCID: https://orcid.org/0000-0003-0631-1494)
- Xiaonan Xue (ORCID: https://orcid.org/0000-0003-2872-8119)
- Pankaj Kumar (ORCID: https://orcid.org/0000-0003-2449-5514)
- J. Philip Kuebler
Institutions
- Albert Einstein College of Medicine (US)
- Cleveland Clinic (US)
- Mayo Clinic (US)
- Memorial Sloan Kettering Cancer Center (US)
- Montefiore Medical Center (US)
- Wayne State University (US)
- Washington University in St. Louis (US)
- Cornell University (US)
- Alliance for Clinical Trials in Oncology (US)
- University of Chicago (US)
- Florida Hospital Cancer Institute (US)
- The Barbara Ann Karmanos Cancer Institute (US)
- Dana-Farber Cancer Institute (US)
- Hôtel-Dieu de Québec (CA)
- Mayo Clinic in Arizona (US)
- Alliance Data (United States) (US)
- Illinois CancerCare (US)
- Columbus Community Clinical Oncology Program (US)
Publication Details
- Journal
- JNCI Journal of the National Cancer Institute
- Published
- 2025-09-20
- DOI
- https://doi.org/10.1093/jnci/djaf281
- Citations
- 2
- Primary Topic
- Colorectal Cancer Treatments and Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.09