Sepsis-induced hypocholesterolemia is linked to low cardiomyocyte membrane cholesterol and impaired catecholamine responsiveness
In a long-term rat model of sepsis, that parallels changes seen in septic patients, cardiomyocyte membrane cholesterol fell with associated decreases in catecholamine responsiveness. These features could be restored by cholesterol infusion, suggesting potential utility as a therapeutic.
Authors
- Miranda J. Melis (ORCID: https://orcid.org/0000-0002-3913-4597)
- Charlotte Gaupp
- Davide T. Andreis (ORCID: https://orcid.org/0000-0001-9415-5158)
- Anna Kleyman
- Mervyn Singer (ORCID: https://orcid.org/0000-0002-1042-6350)
- Klea Mehmetaj
- David Brealey (ORCID: https://orcid.org/0000-0002-1982-3379)
- Walter Pisciotta (ORCID: https://orcid.org/0000-0002-2470-2416)
- Michael W Bauer (ORCID: https://orcid.org/0000-0002-1521-3514)
- Adrian Tibor Press (ORCID: https://orcid.org/0000-0002-6089-6764)
- Bernardo Bollen Pinto (ORCID: https://orcid.org/0000-0002-1281-543X)
- Mark G. Waugh (ORCID: https://orcid.org/0000-0002-7241-3168)
- Waqas Khaliq
- Muska Miller (ORCID: https://orcid.org/0000-0002-5329-5389)
- Daniel A. Hofmaenner
Institutions
- University College London Hospitals NHS Foundation Trust (GB)
- Bury College (GB)
- University Hospital of Zurich (CH)
- University Hospital of Geneva (CH)
- Jena University Hospital (DE)
- Spital Limmattal (CH)
- Azienda Ospedaliera Ospedale Civile di Legnano (IT)
- University College London (GB)
- Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione (IT)
Publication Details
- Journal
- Critical Care
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1186/s13054-025-05638-7
- Citations
- 2
- Primary Topic
- Lipid Membrane Structure and Behavior
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Institute for Health and Care Research
- University College London