Integrative analysis of mRNA, lncRNA, circRNA, and miRNA to investigate the anti-fibrotic activity of silibinin in TGF-β2-treated human trabecular meshwork cells
Silibinin mitigated TGF-β2-induced alterations in the coding and noncoding RNA profiles of HTM cells, presumably contributing to its anti-fibrotic activity. To our knowledge, this is the first study to illustrate the lncRNA and circRNA changes induced by TGF-β2 in HTM cells, and the first study to investigate silibinin's anti-fibrotic effects in HTM cells from the perspective of noncoding RNAs. Our work deepened the understanding of gene regulation by noncoding RNAs in the TGF-β2-induced fibrogenic changes and the anti-fibrotic activity of silibinin in HTM cells.
Authors
- Lina Zhou (ORCID: https://orcid.org/0000-0003-1973-5667)
- Jiantao Wang (ORCID: https://orcid.org/0000-0002-7458-1261)
- Lan Ma (ORCID: https://orcid.org/0000-0002-6610-5871)
- Jinfeng Liu (ORCID: https://orcid.org/0000-0002-0280-2870)
- Lei Zhu (ORCID: https://orcid.org/0000-0003-2087-3629)
- Xueping Wu (ORCID: https://orcid.org/0000-0002-9563-3796)
- Junhong Guo (ORCID: https://orcid.org/0009-0006-6265-6920)
- Xin Liu (ORCID: https://orcid.org/0000-0002-8843-9610)
Institutions
- Xiamen University (CN)
- University Town of Shenzhen (CN)
- Shenzhen Bay Laboratory (CN)
- Tsinghua–Berkeley Shenzhen Institute (CN)
- Peking University Shenzhen Hospital (CN)
- Southern Medical University Shenzhen Hospital (CN)
- He Eye Hospital (CN)
- Tsinghua University (CN)
Publication Details
- Journal
- BMC Genomics
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1186/s12864-025-12027-5
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Sun Yat-sen University
- State Key Laboratory of Ophthalmology