Sustained release of exogeneous fetuin-A from Hyaluronic acid microplates decreases joint degeneration, synovial hyperplasia and muscle damage in a murine post-traumatic osteoarthritis model
This pre-clinical study not only opens new perspectives for the potential use of fetuin-A in OA treatment but confirms µHA as a promising drug carrier in OA.
Authors
- Lara Longobardi (ORCID: https://orcid.org/0000-0002-0156-847X)
- Hüseyin Özkan (ORCID: https://orcid.org/0000-0001-5753-8985)
- Roberto Palomba (ORCID: https://orcid.org/0000-0002-9715-3876)
- Agnese Fragassi
- Paolo Decuzzi (ORCID: https://orcid.org/0000-0001-6050-4188)
- Susan J. Bartlett (ORCID: https://orcid.org/0000-0001-9755-2490)
- Antonietta Greco (ORCID: https://orcid.org/0000-0001-7220-6911)
- Helen H. Willcockson (ORCID: https://orcid.org/0000-0002-3896-5719)
- Richard F. Loeser (ORCID: https://orcid.org/0000-0003-2832-6144)
- Kihyun Kwon (ORCID: https://orcid.org/0000-0003-4224-5762)
Institutions
- University of North Carolina at Chapel Hill (US)
- Emory University (US)
- Italian Institute of Technology (IT)
- Stanford Medicine (US)
- Stanford University (US)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1186/s13075-025-03636-2
- Citations
- 1
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.67
Funders
- European Commission
- Istituto Italiano di Tecnologia
- National Institutes of Health
- University of North Carolina at Chapel Hill
- National Institute of Arthritis and Musculoskeletal and Skin Diseases