Glycyrrhizic acid combined with human adipose-derived MSCs synergistically alleviates the MPP+/MPTP-induced parkinson’s disease by inducing autophagy through PI3K/AKT/HIF-1α pathway
The combination of GA and ADSCs displayed remarkable neuroprotective effects in vitro and in vivo. The underlying mechanism involves the regulation of autophagy via the PI3K/AKT/HIF-1α signaling pathway.
Authors
- Jiakang Zhang
- Xinlang Yu
- Yajie Zhang (ORCID: https://orcid.org/0000-0001-5570-5436)
- Xiaoyu Liu (ORCID: https://orcid.org/0000-0001-5259-7038)
- Yuan Fang (ORCID: https://orcid.org/0009-0009-6968-3739)
- Qi Cui (ORCID: https://orcid.org/0009-0009-5054-5221)
- Lu Yan (ORCID: https://orcid.org/0000-0003-4924-1895)
- Bin Jiang (ORCID: https://orcid.org/0000-0002-4622-9703)
- Wenshan Li (ORCID: https://orcid.org/0000-0002-7968-2678)
- Chengcheng Xu (ORCID: https://orcid.org/0000-0001-5278-3201)
- Qizhi Liu
- Yanjie Jiang
Institutions
- Nanjing University of Chinese Medicine (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1186/s13287-025-04626-6
- Citations
- 1
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- National Natural Science Foundation of China