Prostaglandin E2 stimulates opposing effects on inner and outer blood-retina barrier function
Together these results suggest opposing mechanisms of PGE2 signaling in the retina via two distinct receptors, indicating cell type-specific and likely receptor-specific targets for the potential therapeutic management of DME or other causes of dysfunctional retinal vascular permeability.
Authors
- Gary W. McCollum
- Arthur C. Beall
- Aidan G. Gilmartin
- Taylor E. Smith (ORCID: https://orcid.org/0000-0003-4799-9440)
- Cayla D. Ontko (ORCID: https://orcid.org/0000-0001-6771-6108)
- John S. Penn (ORCID: https://orcid.org/0000-0001-8070-5841)
- Amy K. Stark
Institutions
- Vanderbilt University (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-09-26
- DOI
- https://doi.org/10.3389/fphar.2025.1608376
- Citations
- 1
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.71
Funders
- Research to Prevent Blindness
- Vanderbilt University
- Ögonfonden
- National Institutes of Health