Methadone Blockade of Inward Rectifier Potassium Current Promotes Both Early and Delayed Repolarization Arrhythmias: Mechanistic Insights From Computational Modeling
Methadone promotes both early and delayed repolarization arrhythmias. Early repolarization may be responsible for methadone-related deaths occurring mainly during sleep and occurring more often in men. Blocking I<sub>K1</sub> can work synergistically with other channel blockers to disproportionately increase arrhythmia propensity, greatly increasing methadone's risk when it is combined with other proarrhythmic drugs or under disease conditions.
Authors
- J. T. Green (ORCID: https://orcid.org/0000-0001-5947-9464)
- Mark C. Haigney (ORCID: https://orcid.org/0000-0001-6449-4386)
- Alan Garfinkel (ORCID: https://orcid.org/0000-0002-0500-3740)
- Zhilin Qu (ORCID: https://orcid.org/0000-0001-5217-6022)
- Kalyanam Shivkumar (ORCID: https://orcid.org/0000-0002-4121-1766)
- Patrick F. Walker (ORCID: https://orcid.org/0000-0002-0871-2702)
- Zhaoyang Zhang (ORCID: https://orcid.org/0000-0002-0656-366X)
Institutions
- Ningbo University (CN)
- Uniformed Services University of the Health Sciences (US)
- University of California System (US)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1161/jaha.125.042201
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 0.00