Pretreatment Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte ratio, and Lymphocyte- to-Monocyte Ratio in Extramammary Paget’s Disease: A Retrospective Study

E xtramammary Paget's disease (EMPD) is a rare intraepithelial malignancy arising in apocrine glandrich areas, most often affecting individuals aged 60-80 years.It shows higher prevalence in Caucasian females and Asian males (1).Reported prognostic factors include tumour thickness, invasion depth, nodularity, lymphovascular invasion, perianal location, nodal metastasis, and advanced age (1-4).Systemic inflammatory markers -such as neutrophilto-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and platelet-to-neutrophil ratio (PNR) -have been associated with prognosis in various malignancies (5-7), but their relevance in EMPD remains unclear.This study evaluated the prognostic significance of pretreatment inflammatory markers for disease-specific survival (DSS) in EMPD.