IFNγ regulates MR1 transcription and antigen presentation
Our data support a model where IFNγ from activated MAIT cells or another source stimulates IRF1-dependent MR1 expression and antigen presentation, leading to greater MAIT cell activation. A robust MR1-dependent MAIT cell response may be beneficial for early infection responses, allowing minimal antigen stimulus to generate greater proinflammatory activity.
Authors
- Taylor N. Lust
- Emily A. Larson (ORCID: https://orcid.org/0000-0001-9058-6452)
- Chelsea M. Heisler (ORCID: https://orcid.org/0009-0009-3844-986X)
- Melanie J. Harriff (ORCID: https://orcid.org/0000-0002-1461-5351)
- Megan E. Huber (ORCID: https://orcid.org/0000-0003-4017-5393)
Institutions
- Oregon Health & Science University (US)
- VA Portland Health Care System (US)
- Portland VA Research Foundation (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-26
- DOI
- https://doi.org/10.3389/fimmu.2025.1624767
- Citations
- 2
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 1.59
Funders
- U.S. Department of Veterans Affairs
- Oregon Health and Science University
- National Institutes of Health