PGx-Based in silico Analyses Identifies the Interactive Role of Genes, Glucose Metabolism and Dopaminergic Dysfunctional Pathways with Chronic Cocaine use and Misuse
This in silico PGx analysis demonstrates strong, validated connections based on prior published data and robust computational predictions. Among the findings, the COMT gene was found to be the best-scoring gene here.
Authors
- Edward J. Modestino (ORCID: https://orcid.org/0000-0001-7611-5144)
- Kenneth Blum (ORCID: https://orcid.org/0000-0001-6727-803X)
- Colin Hanna
- Alireza Sharafshah (ORCID: https://orcid.org/0000-0001-8048-9587)
- David Baron (ORCID: https://orcid.org/0000-0001-7670-2613)
- Jag Khalsa (ORCID: https://orcid.org/0000-0002-6534-3616)
- Jean Lud Cadet (ORCID: https://orcid.org/0000-0001-5635-3524)
- Ashim Gupta (ORCID: https://orcid.org/0000-0003-1224-2755)
- Rajendra D. Badgaiyan (ORCID: https://orcid.org/0000-0001-5586-5114)
- Abdalla Bowirrat (ORCID: https://orcid.org/0000-0001-8185-0688)
- Christopher G. Rowan (ORCID: https://orcid.org/0000-0002-4318-2970)
- Igor Elman (ORCID: https://orcid.org/0000-0002-1345-2677)
- Albert Pinhasov (ORCID: https://orcid.org/0000-0001-8116-4565)
- Milan Makale (ORCID: https://orcid.org/0000-0001-5414-0517)
- Brian Fuehrlein (ORCID: https://orcid.org/0000-0002-3202-8089)
- Catherine A. Dennen
- Kai-Uwe Lewandrowski
- Aryeh R Pollack
- Panayotis K. Thanos
- Alexander P. L. Lewandrowski
- Mark S. Gold (ORCID: https://orcid.org/0000-0003-4713-3751)
Institutions
- University of Southern California (US)
- Cambridge Health Alliance (US)
- University of Maryland, Baltimore (US)
- Yale New Haven Hospital (US)
- National Institute on Drug Abuse (US)
- Guilan University of Medical Sciences (IR)
- Washington University in St. Louis (US)
- Thomas Jefferson University Hospital (US)
- Yale University (US)
- University of California San Diego (US)
- Northeast Health (US)
- Desert Institute For Spine Care (US)
- Immungenetics (Germany) (DE)
- Texas Neurology (US)
- Jacobs Institute (US)
- University School (US)
- Fundación Universitaria Sanitas (CO)
- Curry College (US)
- Ariel University (IL)
- Case Western Reserve University (US)
- University at Buffalo, State University of New York (US)
- Universidade Federal do Estado do Rio de Janeiro (BR)
- Western University of Health Sciences (US)
Publication Details
- Journal
- Current Neuropharmacology
- Published
- 2025-09-23
- DOI
- https://doi.org/10.2174/011570159x390146250831143523
- Primary Topic
- Bioinformatics and Genomic Networks
- Type
- article
- Field-Weighted Citation Impact
- 0.00