Allostatic load calculation in a Chilean older-adults cohort reveals the need for age-specific clinical thresholds
Only few studies of Allostatic Load (AL) have been conducted in Latin-American cohorts. Here, we replicated a recently proposed comprehensive algorithm (ALCS) to derive an AL index in a Chilean cohort of cognitive healthy adults. Using data from the GERO cohort (n = 166, age 76.92 ± 5.07 years) we generated an ALCS AL index through and compared for model fit with a purely sample distribution l algorithm (ALES). ALCS largely improved when some clinical values were corrected for ages ≥65, although failed to achieve sufficient goodness of fit. A final inclusion of an additional inflammatory biomarker resulted in further improvement of ALES, but not on ALCS. The ALES algorithm, which do not include clinical thresholds, achieved satisfactory fit after correcting for sample disparities between sexes. This suggests the need to consider the suitability of clinical thresholds developed in younger populations and the need to develop specific thresholds for assessing older adults.
Authors
- Michele Demanet
- Rodrigo Saguez (ORCID: https://orcid.org/0000-0003-2428-7942)
- Patricio Riquelme
- Felipe A. Court (ORCID: https://orcid.org/0000-0002-9394-7601)
- Daniela Thumala (ORCID: https://orcid.org/0000-0003-0392-7031)
- Christian González‐Billault (ORCID: https://orcid.org/0000-0003-0335-1482)
- Felipe Salech (ORCID: https://orcid.org/0000-0003-1575-7658)
- Andrea Slachevsky (ORCID: https://orcid.org/0000-0001-6285-3189)
- Patricia Lillo (ORCID: https://orcid.org/0000-0001-7398-7203)
- Graciela Muñiz‐Terrera (ORCID: https://orcid.org/0000-0002-4516-0337)
- Ingrid Buller‐Peralta (ORCID: https://orcid.org/0000-0002-4427-9897)
- Francisca Damm
Institutions
- Universidad de Santiago de Chile (CL)
- Universidad Mayor (CL)
- Universidad del Desarrollo (CL)
- Buck Institute for Research on Aging (US)
- Fundación Chile (CL)
- Clínica Alemana (CL)
- Instituto de Salud Pública de Chile (CL)
- Colegio Médico de Chile (CL)
- Hospital del Salvador (CL)
- Ohio University (US)
- Fundación Ciencia and Vida (CL)
- Hospital Clínico de la Universidad de Chile (CL)
- Center for Climate and Resilience Research (CL)
- University of Chile (CL)
- University of Valparaíso (CL)
- University of Edinburgh (GB)
Publication Details
- Journal
- npj Dementia
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1038/s44400-025-00032-0
- Citations
- 1
- Primary Topic
- Health Systems, Economic Evaluations, Quality of Life
- Type
- article
- Field-Weighted Citation Impact
- 3.13
Funders
- Agencia Nacional de Investigación y Desarrollo
- Fondo de Financiamiento de Centros de Investigación en Áreas Prioritarias