Evaluation of Fentanyl-Emerged Adverse Events and Pharmacokinetics in Neonates: A Physiologically Based Pharmacokinetic Modeling Approach
Our PBPK model and proposed dosing strategy may contribute to safer and more effective fentanyl use in neonates.
Authors
- Mari Hashimoto
- Kotaro Itohara (ORCID: https://orcid.org/0000-0002-7982-7881)
- Kazuhiro Yamamoto (ORCID: https://orcid.org/0000-0002-7513-6725)
- Walaa Yousef Bassyouni Mahdy (ORCID: https://orcid.org/0000-0002-2277-8521)
- Tomohiro Omura (ORCID: https://orcid.org/0000-0001-5520-253X)
- Kazumichi Fujioka (ORCID: https://orcid.org/0000-0002-9913-6447)
- Yumi Kitahiro (ORCID: https://orcid.org/0000-0002-0263-5726)
- Ikuko Yano (ORCID: https://orcid.org/0000-0001-9517-5628)
- Ruka Nakasone
- Risa Joji
Institutions
- Okayama University (JP)
- Kobe University Hospital (JP)
- Kobe University (JP)
- Assiut University (EG)
Publication Details
- Journal
- Clinical Pharmacokinetics
- Published
- 2025-09-26
- DOI
- https://doi.org/10.1007/s40262-025-01573-6
- Primary Topic
- Anesthesia and Sedative Agents
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Research Foundation for Clinical Pharmacology
- Japan Society for the Promotion of Science