Timing matters: overall treatment time, radiotherapy interruptions, and outcomes in glioblastomas—prognostic significance in different biological sub-groups
This study demonstrates that prolonged OTT and radiotherapy interruptions are independently associated with inferior survival in patients with IDH-wild-type glioblastoma, particularly in biologically favorable subgroups such as MGMT-methylated tumors. These findings underscore the importance of strict adherence to treatment schedules and minimizing avoidable delays. Molecular profiling may aid in identifying patients most vulnerable to the adverse effects of treatment prolongation, supporting a more personalized and time-sensitive approach to GBM management. Further prospective validation is warranted.
Authors
- Alfonso Cerase (ORCID: https://orcid.org/0000-0003-4753-6649)
- Salvatore Chibbaro (ORCID: https://orcid.org/0000-0003-1318-1245)
- Giovanni Rubino
- Paolo Tini (ORCID: https://orcid.org/0000-0003-4826-4809)
- Pierpaolo Pastina (ORCID: https://orcid.org/0000-0002-6428-7560)
- Francesco Marampon (ORCID: https://orcid.org/0000-0002-0588-3039)
- Isacco Desideri (ORCID: https://orcid.org/0000-0002-9880-8387)
- Maria Antonietta Mazzei (ORCID: https://orcid.org/0000-0001-6778-6894)
- Giuseppe Caracciolo Minniti (ORCID: https://orcid.org/0000-0003-1239-1603)
- Giuseppe Battaglia (ORCID: https://orcid.org/0000-0002-1691-6350)
- Flavio Donnini (ORCID: https://orcid.org/0009-0005-4084-3672)
Institutions
- University of Siena (IT)
- Policlinico Umberto I (IT)
- Istituto Neurologico Mediterraneo (IT)
- Azienda Ospedaliera Universitaria Senese (IT)
- University of Florence (IT)
Publication Details
- Journal
- Journal of Neuro-Oncology
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1007/s11060-025-05215-6
- Citations
- 1
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.63