Soluble checkpoint molecules as predictive biomarker for disease activity and long-term outcome in SLE
This study highlights sCD25, sTim-3, and sGal-9 as biomarkers for active SLE and renal and hematologic involvement. Low sCD25 levels were associated with achieving long-term DORIS and LLDAS remission, underscoring the potential of sCD25 as a predictive and sensitive biomarker mandating further clinical validation.
Authors
- Ana‐Luisa Stefanski (ORCID: https://orcid.org/0000-0001-7689-6454)
- Thomas E. Dorner (ORCID: https://orcid.org/0000-0002-5218-1160)
- Bilgin Osmanodja (ORCID: https://orcid.org/0000-0002-8660-0722)
- Annika Wiedemann (ORCID: https://orcid.org/0000-0002-0013-6579)
- Eva Vanessa Schrezenmeier (ORCID: https://orcid.org/0000-0002-0016-7885)
- Héctor Rincón-Arévalo (ORCID: https://orcid.org/0000-0001-5614-7894)
- Franziska Szelinski (ORCID: https://orcid.org/0000-0001-7850-5971)
- Gerhard Krönke (ORCID: https://orcid.org/0000-0002-7566-4325)
- Arman Aue
- L.S. Dreveton
- Jakob Joachim Spencker
Institutions
- Universidad de Antioquia (CO)
- German Rheumatism Research Centre (DE)
- Immanuel Krankenhaus (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-25
- DOI
- https://doi.org/10.3389/fimmu.2025.1685275
- Citations
- 1
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung