A Putative Role for the BCL2 Family of Proteins in the Pathophysiology of ALS

It is concluded that: 1) dysregulation of BCL2 family proteins is implicated in ALS, and 2) blocking Bcl2 alone in the mouse ALS model can markedly reduce the neurodegeneration.

Authors

Anne Lietzke (ORCID: https://orcid.org/0000-0003-1334-1181)
Gerard J. Nuovo (ORCID: https://orcid.org/0000-0002-5351-4721)
Dwitiya Sawant
Candice Crilly

Institutions

MBio Diagnostics (United States) (US)

Publication Details

Journal: CNS & Neurological Disorders - Drug Targets
Published: 2025-09-25
DOI: https://doi.org/10.2174/0118715273426855250910082512
Primary Topic: Amyotrophic Lateral Sclerosis Research
Type: article
Field-Weighted Citation Impact: 0.00

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article

A Putative Role for the BCL2 Family of Proteins in the Pathophysiology of ALS

Anne Lietzke, Gerard J. Nuovo, Dwitiya Sawant, Candice Crilly

Sep 25, 2025

CNS & Neurological Disorders - Drug Targets

Amyotrophic Lateral Sclerosis Research

article

A Putative Role for the BCL2 Family of Proteins in the Pathophysiology of ALS

Anne Lietzke, Gerard J. Nuovo, Dwitiya Sawant, Candice Crilly

September 25, 2025article en

Abstract

It is concluded that: 1) dysregulation of BCL2 family proteins is implicated in ALS, and 2) blocking Bcl2 alone in the mouse ALS model can markedly reduce the neurodegeneration.

CNS & Neurological Disorders - Drug TargetsVol. 25(1)

MBio Diagnostics (United States) (US)

Openalex Percentile: Top 62%

Amyotrophic Lateral Sclerosis Research

DOI Open Access PDF OpenAlex

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A Putative Role for the BCL2 Family of Proteins in the Pathophysiology of ALS — Anne Lietzke, Gerard J. Nuovo, et al. · CNS & Neurological Disorders - Drug Targets (2025) | TGRS Research Map | TGRS