Neurocognitive Decline in Rapid Eye Movement (REM)-Predominant Obstructive Sleep Apnea (OSA) Versus Non-rapid Eye Movement (NREM)-Predominant OSA: A Comparative Study

The detrimental effects of REM-predominant OSA on cognitive function are linked to reduced intracranial oxygen supply, fragmented sleep, and elevated oxidative stress and inflammation. Maintaining continuous positive airway pressure use in the early morning hours, when patients are most prone to discontinuation, is essential for optimal management. Our study emphasizes the need for neurocognitive screening in all newly diagnosed REM-predominant OSA patients to help prevent serious comorbidities. Early and appropriate intervention may mitigate the progression of neurocognitive impairment.