Clinical, immunological, molecular characteristics and outcomes of stem cell transplantation in ZAP70 deficiency: a single-center experience
HSCT remains the only curative treatment for <i>ZAP70</i> deficiency. Myeloablative conditioning regimens appear to promote more robust and durable immune reconstitution. In critically ill patients with severe infections or end-organ damage, reduced-intensity or unconditioned HSCT can be considered as a life-saving approach, although subsequent interventions might be necessary.
Authors
- Sahar Elshorbagi
- Anas M. Alazami (ORCID: https://orcid.org/0000-0002-5625-5585)
- Fai A. AlQahtani
- Hamoud Al‐Mousa (ORCID: https://orcid.org/0000-0003-2508-0062)
- Sultan Albuhairi (ORCID: https://orcid.org/0000-0002-2779-8871)
- Hawazen Saleh Alsaedi (ORCID: https://orcid.org/0000-0002-7478-2514)
- Abbas Hawwari (ORCID: https://orcid.org/0000-0001-9643-6500)
- Nora AlRumayyan
- Rand Arnaout (ORCID: https://orcid.org/0000-0003-3951-5880)
- Ali Alahmari (ORCID: https://orcid.org/0000-0002-8732-5611)
- Mouhab Ayas (ORCID: https://orcid.org/0000-0002-5740-1302)
- Reem Mohammed (ORCID: https://orcid.org/0000-0002-5166-438X)
- Azhar Al Shaqaq
- Bandar Al‐Saud
Institutions
- Alfaisal University (SA)
- King Faisal Specialist Hospital & Research Centre (SA)
- King Fahd Hospital of the University (SA)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-25
- DOI
- https://doi.org/10.3389/fimmu.2025.1656240
- Primary Topic
- Immunodeficiency and Autoimmune Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- King Faisal Specialist Hospital and Research Centre