Helminthic larval stage induces cellular apoptosis via caspase 9-mediated mitochondrial dysfunction
This study identifies caspase 9-mediated apoptosis as a mechanism of helminth-induced brain inflammation and implicates FasL in symptomatic disease progression. These insights enhance our understanding of NCC immunopathogenesis and may inform future therapeutic strategies targeting apoptotic pathways.
Authors
- Katja Steiger (ORCID: https://orcid.org/0000-0002-7269-5433)
- Ulrich Fabien Prodjinotho (ORCID: https://orcid.org/0000-0002-3851-706X)
- Philipp Henneke (ORCID: https://orcid.org/0000-0001-7314-7984)
- Friederike Ebner (ORCID: https://orcid.org/0000-0002-3485-4077)
- Clarissa Prazeres da Costa (ORCID: https://orcid.org/0000-0001-7996-4838)
- Bernard Ngowi (ORCID: https://orcid.org/0000-0001-8738-7903)
- Georg Häcker (ORCID: https://orcid.org/0000-0003-1058-5746)
- Charles Makasi (ORCID: https://orcid.org/0000-0002-2484-617X)
- Vitka Gres (ORCID: https://orcid.org/0000-0002-5034-4691)
- Julia Schluckebier
- Chummy Sikasunge (ORCID: https://orcid.org/0000-0002-5564-2655)
- Nelly Villalobos (ORCID: https://orcid.org/0000-0002-8505-335X)
- Andrea Sylvia Winkler (ORCID: https://orcid.org/0000-0003-3131-6983)
- Dominik Stelzle (ORCID: https://orcid.org/0000-0001-6743-2818)
- Leonardo Elias Sternkopf
- Nikolaus Repgen
Institutions
- University of Freiburg (DE)
- University of Oslo (NO)
- University Medical Center Freiburg (DE)
- Mbeya University of Science and Technology (TZ)
- University of Zambia (ZM)
- German Center for Infection Research (DE)
- Kilimanjaro Christian Medical Centre (TZ)
- Muhimbili National Hospital (TZ)
- Institute of Medical Microbiology and Hygiene (DE)
- National Institute for Medical Research (TZ)
- Technical University of Munich (DE)
- Universidad Nacional Autónoma de México (MX)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-25
- DOI
- https://doi.org/10.3389/fimmu.2025.1603385
- Citations
- 1
- Primary Topic
- Parasitic infections in humans and animals
- Type
- article
- Field-Weighted Citation Impact
- 1.47