Helminthic larval stage induces cellular apoptosis via caspase 9-mediated mitochondrial dysfunction

This study identifies caspase 9-mediated apoptosis as a mechanism of helminth-induced brain inflammation and implicates FasL in symptomatic disease progression. These insights enhance our understanding of NCC immunopathogenesis and may inform future therapeutic strategies targeting apoptotic pathways.

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Publication Details

Journal
Frontiers in Immunology
Published
2025-09-25
DOI
https://doi.org/10.3389/fimmu.2025.1603385
Citations
1
Primary Topic
Parasitic infections in humans and animals
Type
article
Field-Weighted Citation Impact
1.47
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Helminthic larval stage induces cellular apoptosis via caspase 9-mediated mitochondrial dysfunction

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Frontiers in Immunology
Parasitic infections in humans and animals
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Helminthic larval stage induces cellular apoptosis via caspase 9-mediated mitochondrial dysfunction

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article en
1 citations

Abstract

This study identifies caspase 9-mediated apoptosis as a mechanism of helminth-induced brain inflammation and implicates FasL in symptomatic disease progression. These insights enhance our understanding of NCC immunopathogenesis and may inform future therapeutic strategies targeting apoptotic pathways.

Frontiers in ImmunologyVol. 16
University of Freiburg (DE), University of Oslo (NO), University Medical Center Freiburg (DE), Mbeya University of Science and Technology (TZ), University of Zambia (ZM), German Center for Infection Research (DE), Kilimanjaro Christian Medical Centre (TZ), Muhimbili National Hospital (TZ), Institute of Medical Microbiology and Hygiene (DE), National Institute for Medical Research (TZ), Technical University of Munich (DE), Universidad Nacional Autónoma de México (MX)
Openalex Percentile: Top 15%
Parasitic infections in humans and animals
1.47
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