Neurostructural Correlates of Polygenic Risk for Coronary Artery Disease in Relation to Youth Bipolar Disorder
Higher CAD-PRS was associated with lower regional gray matter structure in youth, in regions implicated in BD. Findings were more pronounced in the BD group, particularly among females, and related to cortical thickness specifically. Future longitudinal studies are needed to examine the association of CAD-PRS with neurodevelopmental changes over time and to discern mechanisms underlying the observed findings.
Authors
- Nidhi P. Kulkarni (ORCID: https://orcid.org/0000-0002-4047-2542)
- Kody G. Kennedy (ORCID: https://orcid.org/0000-0002-4510-188X)
- Megan Mio (ORCID: https://orcid.org/0000-0002-7411-7995)
- L. Trevor Young (ORCID: https://orcid.org/0000-0003-0409-5468)
- Bradley J. MacIntosh (ORCID: https://orcid.org/0000-0001-7300-2355)
- Clement C. Zai (ORCID: https://orcid.org/0000-0003-0496-7262)
- Benjamin Alan Goldstein (ORCID: https://orcid.org/0000-0001-5261-3632)
Institutions
- Oslo University Hospital (NO)
- Centre for Addiction and Mental Health (CA)
- University of Toronto (CA)
- Ontario Brain Institute (CA)
Publication Details
- Journal
- Bipolar Disorders
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1111/bdi.70065
- Citations
- 2
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 3.63