Impact of Hypertension on the Outcomes of Patients With High-Grade Gliomas: A Propensity-Matched Study From a Global Federated Health Research Network

The GBM+HTN cohort showed significantly higher risk of all-cause mortality (HR 1.18; 95% CI 1.094-1.271; p<0.000), cerebral edema (HR 1.359; 95% CI 1.236-1.494; p<0.001), seizures (HR 1.624; 95% CI 1.459-1.808; p=0.007), and hemorrhagic stroke (HR 1.255; 95% CI 1.038-1.516; p=0.015). The ODG+HTN cohort demonstrated significantly increased risk of all-cause mortality (HR 1.398; 95% CI 1.040-1.879; p=0.001), emergency endotracheal intubation (HR 1.381; 95% CI 0.590-3.230; p=0.012), and cerebral edema (HR 0.904; 95% CI 0.680-1.203; p=0.023). There were no significant differences between the HTN and control cohorts in the astrocytoma group. Conclusions: Patients with high-grade gliomas and HTN differ significantly. Patients with HTN appear to be at a higher risk of all-cause mortality, cerebral edema, seizures, and emergency endotracheal intubation, depending on tumor type. Further research is warranted.