Mu or delta opioid receptor antagonists increase the expression of social conditioned place preference in early adolescent mice
Our findings support a modified version of the state-dependent mu-opioid receptor model of social behavior, where the effects of opioid ligands are not reversed during development but rather weaken or disappear with age. Furthermore, the results indicate that interactions with siblings in early adolescent mice are motivated by negative reinforcement, whereas those in late adolescence are motivated by positive reinforcement.
Authors
- Jan Rodriguez Parkitna (ORCID: https://orcid.org/0000-0003-0367-2331)
- Łukasz Szumiec (ORCID: https://orcid.org/0000-0001-8962-1273)
- Marta Klimczak (ORCID: https://orcid.org/0000-0003-0653-4030)
- Rafał Ryguła (ORCID: https://orcid.org/0000-0002-3662-5833)
- Klaudia Misiołek (ORCID: https://orcid.org/0000-0003-1379-2118)
- Barbara Ziółkowska (ORCID: https://orcid.org/0000-0002-6782-7737)
- Zofia Harda (ORCID: https://orcid.org/0000-0001-7183-2195)
- Magdalena Chrószcz (ORCID: https://orcid.org/0000-0002-3157-458X)
- Maria Kaczmarczyk-Jarosz
- Aleksandra Rzeszut
Institutions
- Maj Institute of Pharmacology (PL)
- Polish Academy of Sciences (PL)
Publication Details
- Journal
- Psychopharmacology
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1007/s00213-025-06902-y
- Citations
- 1
- Primary Topic
- Neuroendocrine regulation and behavior
- Type
- article
- Field-Weighted Citation Impact
- 2.44