Mineralocorticoid receptor inhibition in parietal epithelial cells prevents focal segmental glomerulosclerosis and crescentic glomerulonephritis
Together, our results highlight the common role of MR signaling in the pathophysiology of extra-capillary glomerulopathies, FSGS, and crescentic glomerulonephritis. This supports the use of MR antagonists as potential complementary therapeutic agents with original modes of action for severe diseases.
Authors
- Sheerazed Boulkroun (ORCID: https://orcid.org/0000-0002-8796-7534)
- Maria‐Christina Zennaro (ORCID: https://orcid.org/0000-0001-5449-9191)
- Florian Garo
- Carole Hénique-Gréciet
- Hélène Lazareth (ORCID: https://orcid.org/0000-0002-1500-3736)
- Alexandre Karras (ORCID: https://orcid.org/0000-0002-3075-7739)
- May Fayad (ORCID: https://orcid.org/0009-0007-1665-7698)
- Léa Guyonnet (ORCID: https://orcid.org/0000-0003-4815-1193)
- Marcus J. Moeller (ORCID: https://orcid.org/0000-0002-1709-3499)
- Olivia Lenoir (ORCID: https://orcid.org/0000-0001-8107-6987)
- Isabelle Giscos-Douriez
- Nasreddine Saïdi (ORCID: https://orcid.org/0000-0002-5036-1811)
- Pierre‐Louis Tharaux (ORCID: https://orcid.org/0000-0002-6062-5905)
- Angélique Rocha (ORCID: https://orcid.org/0000-0002-3884-7165)
Institutions
- Délégation Paris 5 (FR)
- Inserm (FR)
- Université Paris-Est Créteil (FR)
- Université Paris Cité (FR)
- Sorbonne Paris Cité (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Center for Infection and Immunity of Lille (FR)
- Hôpital Européen Georges-Pompidou (FR)
- Centre Hospitalier Universitaire de Nîmes (FR)
- Hôpital Européen (FR)
- Paris Cardiovascular Research Center (FR)
- Université de Nîmes (FR)
- Institut Curie (FR)
- RWTH Aachen University (DE)
- FH Aachen (DE)
Publication Details
- Journal
- Kidney International
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1016/j.kint.2025.07.037
- Citations
- 2
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 2.86