In-depth analysis of metabolic hormones and inflammatory markers following Roux-en-Y gastric bypass in humans and rodents: similarities and differences
Preoperative GLP-1 levels in humans correlate with weight loss after RYGB and could potentially be predictive. The investigated rat model shows largely comparable patterns of incretins and adipokines. Given its physiological similarity, this model is suitable for testing pharmacological agents that mimic anorexigenic hormones, potentially guiding novel treatments for severe obesity.
Authors
- Ilja Balonov (ORCID: https://orcid.org/0000-0001-5253-7879)
- Lukas Scheller (ORCID: https://orcid.org/0000-0002-0912-1808)
- Martin Faßnacht (ORCID: https://orcid.org/0000-0001-6170-6398)
- Ann‐Cathrin Koschker (ORCID: https://orcid.org/0000-0002-7085-8657)
- Ulrich Dischinger (ORCID: https://orcid.org/0009-0008-4885-9355)
- Max Kurlbaum (ORCID: https://orcid.org/0000-0002-8438-2127)
- Florian Seyfried (ORCID: https://orcid.org/0000-0002-5915-8692)
- Simon Kloock (ORCID: https://orcid.org/0009-0005-4610-0888)
- Julia Hasinger
Institutions
- University of Würzburg (DE)
- LMU Klinikum (DE)
- Universitäts-Kinderklinik Würzburg (DE)
- Universitätsklinikum Würzburg (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Diabetes Research and Clinical Practice
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1016/j.diabres.2025.112923
- Citations
- 1
- Primary Topic
- Bariatric Surgery and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 2.01