Rapid diagnosis and targeted therapy of Chlamydia psittaci pneumonia: The clinical value of quantitative metagenomic next-generation sequencing

Chlamydia psittaci (C. psittaci) pneumonia poses significant challenges for early diagnosis due to its non-specific clinical presentation and imaging characteristics. Delayed etiological diagnosis and inappropriate treatment often lead to disease exacerbation. In this case, the patient's initial empirical treatment proved ineffective, and the condition worsened. The diagnosis of C. psittaci infection was ultimately confirmed through quantitative metagenomic next-generation sequencing (Q-mNGS™). Following targeted azithromycin therapy, the patient's symptoms and imaging findings markedly improved. This case underscores the clinical value of metagenomic next-generation sequencing (mNGS) in the early diagnosis and targeted treatment of C. psittaci pneumonia in non-immunocompromised individuals.