Clinico-pathological correlation in unilateral cortical encephalitis treated with tocilizumab after first-line treatment failure
Tocilizumab-an IL-6 receptor blocker-was selected given the pleiotropic role of IL-6 in proinflammatory CD4<sup>+</sup>T-cell differentiation (Th17/Treg imbalance) and innate immune-driven CNS inflammation. This case illustrates the utility of clinico-pathological correlation and cytokine profiling in guiding immunotherapy selection in antibody-negative autoimmune encephalitis.
Authors
- Saeed Asiry (ORCID: https://orcid.org/0000-0003-4568-6061)
- Samir Alkabie (ORCID: https://orcid.org/0000-0001-5596-514X)
- Ana Marija Franceschi (ORCID: https://orcid.org/0000-0003-2577-9738)
- Derek J. Chong (ORCID: https://orcid.org/0000-0003-2377-5813)
- Souhel Najjar (ORCID: https://orcid.org/0000-0002-4701-1503)
- SM Ali
Institutions
- Lenox Hill Hospital (US)
- Donald & Barbara Zucker School of Medicine at Hofstra/Northwell (US)
Publication Details
- Journal
- Journal of Neuroimmunology
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1016/j.jneuroim.2025.578764
- Primary Topic
- Autoimmune Neurological Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00